Genetics & Foetal Development
Posted: Wed May 19, 2004 9:39 am
Hello Everyone,
This may not be the best place to post this, but search as I might, I cannot find the thread I was looking for. So, here it is...
Somewhere on this forum I read a post by an SO saying, if I remember correctly, that all babies start off as female. If I've recollected wrongly, please forgive me, but I'm geriatric, and my memory's going these days.
However, assuming that I did recollect correctly, here's what actually happens...
In human somatic (body) cells there are normally 46 chromosomes made up of 23 pairs. 44 of the 46 are called autosomes because they are not thought to determine gender. The other two are called sex chromosomes. Normal males have a relatively large X and a small Y sex chromosome and normal females have two X sex chromosomes.
When the germ, or generative cells, are formed in the body of the adult, these sex chromosomes become separated, so that a sperm carries either a single X or a single Y chromosome, whilst every egg carries a single X chromosome. At conception the new embryo will be XX or XY, according to whether the egg, which is always X, was fertilized by an X-bearing sperm or by a Y-bearing sperm. Thus the sperm controls the genetic sex of the child.
Although the sex of the embryo is determined at the time of conception, anatomical differences don't show until approximately two months later. In this 'indifferent stage' every foetus has the primitive structures necessary for either a male or a female system: there are both Wolffian ducts and Mullerian ducts.
Gonad is the term given to the undifferentiated organ that will later become either a testis an ovary. Testes develop earlier than ovaries. In an XY foetus, the gonads develop into testes. The testes then cause the Wolffian ducts to develop into the rest of the internal male system, and the Mullerian ducts to be suppressed. In an XX foetus, the gonads develop into ovaries, the Mullerian ducts then form the rest of the female internal system and the Wolffian ducts are suppressed.
It is important to understand not only that there is a single primitive structure in the indifferent stage from which the male or the female organs develop, but that, each reproductive organ in either sex has a counterpart in the opposite sex. For example, the penis of the male and the much smaller clitoris of the female both come from the embryonic genital tubercle or phallus. Men have a vestigial uterus, the utriculus masculinus in the prostate and women have a homologue prostate in the glands at the lower end of the urethra.
Every foetus, whether genetically male (XY) or female (XX), starts life with the capacity to develop either a male or female reproductive system. All foetuses have non-specific genitals for the first 8 weeks or so after conception. After a few weeks, in an XY foetus the non-specific genitals develop into male genitals under the influence of male hormones (androgens).
If the child is conceived with male (XY) sex chromosomes, embryonic testes develop inside the body and start to produce androgens. In some cases these androgens cannot complete the male genital development due to a rare inability to use the androgens that the testes produce so the development of the external genitals continues along female lines.
So in a genetically male (XY) foetus the active intervention of male hormones (androgens) is needed to produce a fully male system. A female body type with female external genitalia is the basic underlying human form.
I hope that clears it up for you.
Regards,
Caroline.
This may not be the best place to post this, but search as I might, I cannot find the thread I was looking for. So, here it is...
Somewhere on this forum I read a post by an SO saying, if I remember correctly, that all babies start off as female. If I've recollected wrongly, please forgive me, but I'm geriatric, and my memory's going these days.
However, assuming that I did recollect correctly, here's what actually happens...
In human somatic (body) cells there are normally 46 chromosomes made up of 23 pairs. 44 of the 46 are called autosomes because they are not thought to determine gender. The other two are called sex chromosomes. Normal males have a relatively large X and a small Y sex chromosome and normal females have two X sex chromosomes.
When the germ, or generative cells, are formed in the body of the adult, these sex chromosomes become separated, so that a sperm carries either a single X or a single Y chromosome, whilst every egg carries a single X chromosome. At conception the new embryo will be XX or XY, according to whether the egg, which is always X, was fertilized by an X-bearing sperm or by a Y-bearing sperm. Thus the sperm controls the genetic sex of the child.
Although the sex of the embryo is determined at the time of conception, anatomical differences don't show until approximately two months later. In this 'indifferent stage' every foetus has the primitive structures necessary for either a male or a female system: there are both Wolffian ducts and Mullerian ducts.
Gonad is the term given to the undifferentiated organ that will later become either a testis an ovary. Testes develop earlier than ovaries. In an XY foetus, the gonads develop into testes. The testes then cause the Wolffian ducts to develop into the rest of the internal male system, and the Mullerian ducts to be suppressed. In an XX foetus, the gonads develop into ovaries, the Mullerian ducts then form the rest of the female internal system and the Wolffian ducts are suppressed.
It is important to understand not only that there is a single primitive structure in the indifferent stage from which the male or the female organs develop, but that, each reproductive organ in either sex has a counterpart in the opposite sex. For example, the penis of the male and the much smaller clitoris of the female both come from the embryonic genital tubercle or phallus. Men have a vestigial uterus, the utriculus masculinus in the prostate and women have a homologue prostate in the glands at the lower end of the urethra.
Every foetus, whether genetically male (XY) or female (XX), starts life with the capacity to develop either a male or female reproductive system. All foetuses have non-specific genitals for the first 8 weeks or so after conception. After a few weeks, in an XY foetus the non-specific genitals develop into male genitals under the influence of male hormones (androgens).
If the child is conceived with male (XY) sex chromosomes, embryonic testes develop inside the body and start to produce androgens. In some cases these androgens cannot complete the male genital development due to a rare inability to use the androgens that the testes produce so the development of the external genitals continues along female lines.
So in a genetically male (XY) foetus the active intervention of male hormones (androgens) is needed to produce a fully male system. A female body type with female external genitalia is the basic underlying human form.
I hope that clears it up for you.
Regards,
Caroline.